Inhibitory activity of CXCR4 attenuates intervertebral disc degeneration by regulating TXNIP/NLRP3 expression

Purpose: To explore the inhibitory effect and mechanism of action CXCR4 on intervertebral disc degeneration.Methods: The expression was assessed in different degrees degenerate tissues. Nucleus pulposus (NP) cells-induced degeneration were obtained using interleukin 1 beta (IL-1β) stimulation. inhibitor, AMD 3100, employed to resist function CXCR4, order determine whether inhibition acted by targeting TXNIP/NLRP3 axis.Results: Expression increased severely degenerated IL-1β activated promoted progression degeneration, but AMD3100 treatment reversed effects IL-1β. Moreover, TXNIP NLRP3 significantly suppressed stimuli.Conclusion: results demonstrate that prevents NP cells from degradation regulating signaling pathway, thus indicating this approach could be effective management degeneration.